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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Transdermal Drug Delivery Systems01:18

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Articles linked to this work by shared authors, journal, and citation graph.

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Classification of Follow-up Rehabilitation ("AHB") in the Context of Postoperative Cochlear Implant (CI) Care.

Laryngo- rhino- otologie·2025
Same author

Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025.

HNO·2025
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[Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025. German version].

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[Negative pressure in the ear canal with consequences].

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The German cochlear implant registry: one year experience and first results on demographic data.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024
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[The WHO grades of hearing loss : A consensus on the German version].

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Related Experiment Video

Updated: Mar 10, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

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Intracochlear drug delivery in combination with cochlear implants : Current aspects.

S K Plontke1, G Götze2, T Rahne2

  • 1Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany. stefan.plontke@uk-halle.de.

HNO
|December 10, 2016
PubMed
Summary

Local drug delivery to the inner ear improves cochlear implant (CI) function. A biocompatible system successfully delivered dexamethasone intracochlear, enhancing CI outcomes in two patients.

Keywords:
CochleaCochlear implantDrug deliveryImpedanceInner ear

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Area of Science:

  • Otorhinolaryngology
  • Biomedical Engineering
  • Pharmacology

Background:

  • Local drug delivery to the inner ear offers advantages over systemic administration.
  • Current methods include extracochlear and intracochlear administration, often combined with auditory prostheses.
  • Drug-eluting electrode carriers aim to improve cochlear implant (CI) rehabilitation by protecting neural structures and promoting growth.

Purpose of the Study:

  • To evaluate the efficacy of a biocompatible, resorbable drug-delivery system for controlled intracochlear drug release in CI patients.
  • To investigate the use of dexamethasone delivered via an intracochlear system to manage progressive speech discrimination reduction and increased impedance.
  • To compare intracochlear drug concentrations from different dexamethasone application strategies using a computer model.

Main Methods:

  • Case reports of two CI patients receiving intracochlear placement of a resorbable drug-delivery system.
  • Controlled release of dexamethasone for treating progressive speech discrimination loss and increased impedance.
  • Computer modeling to calculate and compare inner ear drug levels for various local application strategies.

Main Results:

  • Successful intracochlear placement of a biocompatible, resorbable drug-delivery system in two CI patients.
  • Treatment of progressive speech discrimination reduction and increased impedance was achieved.
  • Calculated intracochlear dexamethasone concentrations were compared across different application strategies.

Conclusions:

  • Local, controlled drug delivery via resorbable systems is a viable strategy to enhance CI rehabilitation.
  • Intracochlear dexamethasone delivery can effectively manage adverse CI-related symptoms.
  • Computer modeling provides a valuable tool for optimizing local drug delivery strategies in the inner ear.