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Updated: Mar 10, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Published on: April 4, 2012
Systems Genetics of Obesity
Gudrun A Brockmann1, Danny Arends2, Sebastian Heise2
1Faculty of Life Sciences, Albrecht Daniel Thaer-Institut, Humboldt-Universität zu Berlin, Invalidenstraße 42, 10115, Berlin, Germany. gudrun.brockmann@agrar.hu-berlin.de.
Mapping obesity genes is complex. This study uses physicochemical adipose tissue characterization in BXD mice to identify genetic factors influencing obesity, leveraging the GeneNetwork platform for analysis.
Area of Science:
- Genetics
- Obesity Research
- Animal Models
Background:
- Obesity is a complex trait influenced by multiple genes and environmental factors.
- Identifying specific gene variants contributing to obesity requires advanced genetic strategies.
- Simple fat content measurement is insufficient for pinpointing causative genes.
Purpose of the Study:
- To investigate the genetic determinants of obesity by analyzing adipose tissue characteristics.
- To demonstrate how structured mouse populations and integrated data analysis can elucidate complex phenotypes.
- To identify genes associated with collagen content in adipose tissue within BXD recombinant inbred lines.
Main Methods:
- Utilized BXD recombinant inbred mouse lines for genetic analysis.
- Performed physicochemical characterization of adipose tissue.
- Employed the GeneNetwork platform for data integration and gene mapping.
Main Results:
- Physicochemical characterization of adipose tissue provided insights into the obese phenotype.
- The study successfully searched for genes contributing to collagen content in BXD mouse adipose tissue.
- GeneNetwork facilitated the analysis of complex genetic data.
Conclusions:
- Integrated analysis of physicochemical adipose tissue data in BXD mice aids in understanding obesity genetics.
- The approach simplifies the complexity of identifying genetic factors underlying obesity.
- This strategy is effective for discovering genetic determinants of complex traits like obesity.
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