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Structural Conversions of Synthetic and Protein-Bound Iron-Sulfur Clusters
1Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
Chemical Reviews
|December 10, 2016
Summary
Synthetic iron-sulfur clusters exhibit diverse structures and reactivity. This study highlights cluster conversions, where iron-sulfur cores transform into new structures, offering insights into their modular nature and biological relevance.
Area of Science:
- Inorganic Chemistry
- Bioinorganic Chemistry
- Materials Science
Background:
- Synthetic iron-sulfur clusters ([FemSqLl]z) possess diverse structures, some mimicking those in proteins.
- Previous research predominantly focused on the physical properties of these clusters.
Purpose of the Study:
- To investigate the reactivity of synthetic iron-sulfur clusters, specifically focusing on cluster conversion reactions.
- To present a comprehensive overview of core conversions, including those occurring in biological systems.
Main Methods:
- Systematic presentation and depiction of various structural core types.
- Diagrammatic summarization of identified core conversion pathways.
- Analysis of reactions such as self-assembly, fragment condensation, and dissociation.
Main Results:
- Identified and presented an extensive body of iron-sulfur cluster core conversions, many previously unrecognized.
- Highlighted the central role of the cubane-type Fe4S4 core in conversion chemistry.
- Demonstrated that iron-sulfur cores can be viewed as modular units undergoing transformations.
Conclusions:
- Iron-sulfur cluster core conversions represent a significant aspect of their reactivity.
- The modular nature of iron-sulfur cores facilitates transformations into diverse structures.
- Understanding these conversions provides new perspectives on iron-sulfur cluster chemistry in both synthetic and biological contexts.
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