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Total Synthesis of Tetraketide and Cryptorigidifoliol I via a Sequential Allylation Strategy
Birakishore Padhi1,2, G Sudhakar Reddy1,2, Debendra K Mohapatra1,2
1Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
Abstract:
A unified and efficient synthetic route for both tetraketide (1) and cryptorigidifoliol I (2) has been devised successfully from commercially available starting materials in 11 and 17 steps, with 16% and 11% overall yields, respectively. Highlights of the syntheses involved sequential Lewis acid-catalyzed highly regio- and diastereoselective allylations and intramolecular Mitsunobu lactonization.
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