Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

17.0K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
17.0K
DNA Helicases00:55

DNA Helicases

24.7K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.7K
The DNA Replication Fork01:02

The DNA Replication Fork

42.2K
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
42.2K
The DNA Replication Fork01:02

The DNA Replication Fork

19.0K
19.0K
The DNA Helix01:16

The DNA Helix

160.5K
Overview
160.5K
The DNA Helix01:07

The DNA Helix

31.3K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
31.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease.

Acta neuropathologica·2026
Same author

Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

P450 Electron transfer: Towards in vitro NAD(P)H-independent biocatalysis.

Journal of inorganic biochemistry·2025
Same author

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same journal

Proton-Gated Torsional Spring for Molecular Energy Storage.

Journal of the American Chemical Society·2026
Same journal

Topologically Programmed Dual-Channel Covalent Organic Frameworks Decouple Gas and Ion Fluxes for Acidic CO<sub>2</sub> Electroreduction.

Journal of the American Chemical Society·2026
Same journal

Plasmonic Re-Excitation Enables Superoxide-Mediated Ethane Conversion to Acetic Acid under Visible Light.

Journal of the American Chemical Society·2026
Same journal

Photocatalytic Controlled Halodefluorination of Perfluoroalkyl Compounds Using <i>N</i>-Arylphenothiazines.

Journal of the American Chemical Society·2026
Same journal

Photoinduced Disproportionation Enables Oxidative Addition of Aryl Iodides at a Gallium(I) Center.

Journal of the American Chemical Society·2026
Same journal

Biocatalytic C3 β-<i>O</i>-Glycosylation of Triterpenes and Sterols to Synthesize Natural and Unnatural Saponins.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: Mar 10, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

8.7K

Helix-Dependent Spin Filtering through the DNA Duplex.

Theodore J Zwang1, Sylvia Hürlimann1, Michael G Hill2

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

Journal of the American Chemical Society
|December 10, 2016
PubMed
Summary
This summary is machine-generated.

Electrons travel through DNA in a spin-selective way, with DNA’s structure acting like a switch. Changing DNA’s handedness alters which electron spin moves more efficiently, revealing insights into spin transport.

More Related Videos

CD Spectroscopy to Study DNA-Protein Interactions
06:48

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

7.8K
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

1.4K

Related Experiment Videos

Last Updated: Mar 10, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
08:28

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

8.7K
CD Spectroscopy to Study DNA-Protein Interactions
06:48

CD Spectroscopy to Study DNA-Protein Interactions

Published on: February 10, 2022

7.8K
Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
05:37

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

1.4K

Area of Science:

  • Molecular Biophysics
  • Spintronics
  • Nanotechnology

Background:

  • Emerging research indicates spin-selective electron transport through chiral molecules like DNA.
  • The fundamental mechanisms driving this spin selectivity in DNA remain largely unexplored.
  • Understanding spin transport in DNA is crucial for developing novel spintronic devices.

Purpose of the Study:

  • To investigate the origin of spin selectivity in electron transport through hydrated duplex DNA.
  • To explore the role of DNA helicity and charge transport in spin-dependent electron migration.
  • To determine if DNA's supramolecular organization influences spin selectivity.

Main Methods:

  • Experiments utilizing magnetized DNA-modified electrodes to probe electron transport.
  • Analysis of spin-selective electron transport yields through hydrated duplex DNA.
  • Comparison of spin selectivity in right-handed B-DNA and left-handed Z-DNA conformations.

Main Results:

  • Demonstrated differential migration yields for the two electron spins through duplex DNA.
  • Confirmed that spin selectivity is dependent on charge transport occurring within the DNA duplex.
  • Observed a diode-like switching of spin selectivity upon transitioning DNA between B- and Z-forms, directly correlating with DNA helicity.

Conclusions:

  • The helicity of DNA, specifically its supramolecular organization, dictates spin selectivity in electron transport.
  • Conformational changes in DNA can dynamically switch the preferred pathway for specific electron spins.
  • Spin selectivity in DNA is governed by the overall structure, not just individual monomer chirality.