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Insertion of Arynes into P-O Bonds: One-Step Simultaneous Construction of C-P and C-O Bonds
Na Qi1, Ning Zhang1, Srinivasa Rao Allu1
1School of Pharmaceutical Sciences and Innovative Drug Research Centre , Chongqing University , 55 Daxuecheng South Road, Shapingba, Chongqing 401331, P. R. China.
Abstract:
The insertion of arynes into P-O bonds for the preparation of o-hydroxy-substituted arylphosphine oxides, -phosphinates, and -phosphonates is described. This novel reaction leads to the simultaneous formation of C-P and C-O bonds in one step with good yields and regioselectivities under mild and transition-metal-free conditions. The easy follow-up transformations of the resulting o-hydroxyl group extend these reactions to the facile construction of other ortho-substituted arylphosphorus compounds.
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