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Published on: January 5, 2015
Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles
Giuseppe Ferrauto1, Fabio Carniato, Enza Di Gregorio
1Department of Molecular Biotechnology and Health Sciences, University of Turin, Via Nizza 52, 10126 Turin, Italy. silvio.aime@unito.it.
Abstract:
Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.
