Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

820
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
820
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

813
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
813
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

918
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
918
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

484
Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
484
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

684
Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
684
Modeling with Differential Equations01:25

Modeling with Differential Equations

138
Population dynamics can be described mathematically by considering the population size P(t) as a function of time. The rate of change of the population is then represented by the derivative of P(t). A simple assumption is that the rate of growth is proportional to the size of the population itself. This leads to an exponential growth model, where the population increases rapidly without bound. While this is a useful first approximation, it does not reflect realistic long-term...
138

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in Non-Invasive Myocardial Stiffness Assessment and Clinical Applications in Hypertrophic Cardiomyopathy.

Reviews in cardiovascular medicine·2026
Same author

Multicompartment Darcy Flow Model With Patient-Specific Parameterization: Effect of Heterogeneity and Anisotropy in Porous Parameters.

International journal for numerical methods in biomedical engineering·2025
Same author

A discrete-to-continuum model for the human cornea with application to keratoconus.

Royal Society open science·2024
Same author

Reprising Heberden's description of angina pectoris after 250 years.

European heart journal·2022
Same author

Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19-a data-driven retrospective cohort study.

Journal of the Royal Society of Medicine·2022
Same author

Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19.

Annals of intensive care·2022
Same journal

Functional and Structural Analysis of Auxetic Metamaterial Stent Designs for Thoracic Aortic Aneurysms Using Finite Element Simulation.

International journal for numerical methods in biomedical engineering·2026
Same journal

Dynamic Simulation of Male Bladder Outlet Obstruction: Flow Characteristics and Novel Quantitative Indicators.

International journal for numerical methods in biomedical engineering·2026
Same journal

Path Planning of Flexible Needle Based on Improved Particle Swarm Optimization Algorithm.

International journal for numerical methods in biomedical engineering·2026
Same journal

A Fully Automated Pipeline for Vertebral Structural Assessment From Medical Images. Application Under Metastatic Conditions.

International journal for numerical methods in biomedical engineering·2026
Same journal

Evaluation of Degradable Mg-Alloy Implants for Femoral Neck Fractures: Subject-Specific Finite Element Analysis Integrated With Bone Remodelling.

International journal for numerical methods in biomedical engineering·2026
Same journal

Patient-Specific In Silico Prediction of Outcomes of Partial Continuous-Flow LVAD Treatment in Peripartum Cardiomyopathy.

International journal for numerical methods in biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Mar 10, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Modelling mitral valvular dynamics-current trend and future directions.

Hao Gao1, Nan Qi1, Liuyang Feng1

  • 1School of Mathematics and Statistics, University of Glasgow, UK.

International Journal for Numerical Methods in Biomedical Engineering
|December 10, 2016
PubMed
Summary
This summary is machine-generated.

Computational modeling of the human mitral valve is advancing to understand its complex biomechanics. This research reviews current models, aiding new treatments for mitral valve diseases.

Keywords:
fluid-structure interactionleft ventriclemitral valvenumerical methodssoft tissue

More Related Videos

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.6K
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K

Related Experiment Videos

Last Updated: Mar 10, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.6K
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Computational Biology

Background:

  • Mitral valve dysfunction is a significant global health issue, causing substantial morbidity and mortality.
  • Understanding mitral valve biomechanics is crucial for developing effective treatments and diagnostic tools.
  • Previous research has focused less on the mitral valve compared to the aortic valve due to its complexity.

Purpose of the Study:

  • To review the current state-of-the-art in computational modeling of the human mitral valve.
  • To explore various modeling approaches, including static, dynamic, fluid-structure interaction, and left ventricle interaction models.
  • To identify challenges and future directions in mitral valve computational modeling.

Main Methods:

  • Literature review of computational modeling techniques applied to the mitral valve.
  • Analysis of different model types: static, dynamic, fluid-structure interaction (FSI), and left ventricle (LV) interaction.
  • Synthesis of findings on the increasing sophistication of mitral valve models.

Main Results:

  • Computational modeling of the mitral valve is a rapidly advancing field.
  • Sophisticated models incorporating fluid-structure and ventricle interactions are becoming more prevalent.
  • Despite challenges, modeling offers significant potential for understanding and treating mitral valve diseases.

Conclusions:

  • Computational modeling is essential for advancing the understanding of mitral valve biomechanics.
  • Continued development in computational technology and imaging will enhance model accuracy and utility.
  • Future research should focus on overcoming current challenges to fully realize the potential of mitral valve modeling for clinical applications.