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Mobility measures differentiate falls risk status in persons with multiple sclerosis: An exploratory study.

Emerson Sebastião1, Yvonne C Learmonth1, Robert W Motl2

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Neurorehabilitation
|December 10, 2016
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Summary

Falls are a major concern for individuals with multiple sclerosis (MS). Mobility impairments, specifically the MS Walking Scale (MSWS-12) and 6-Minute Walk (6MW) scores, are key predictors of increased fall risk in MS patients.

Keywords:
Disabilityfalls riskneurological disorderpredictorswalking ability

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Area of Science:

  • Neurology
  • Rehabilitation Science
  • Gerontology

Background:

  • Falls pose a significant challenge for individuals with multiple sclerosis (MS).
  • Understanding fall risk factors is crucial for effective intervention strategies in MS.
  • Distinct fall risk profiles exist within the MS population.

Purpose of the Study:

  • To differentiate mobility, postural control, and cognitive metrics between individuals with MS categorized by fall risk.
  • To identify predictors of fall risk group membership in MS using discriminant analysis.

Main Methods:

  • Forty-seven individuals with MS completed the Activities-Balance Confidence (ABC) Scale and underwent mobility, balance, and cognitive assessments.
  • Participants wore accelerometers for 7-day step count monitoring.
  • Fall risk groups (Increased Fall Risk - IFR, Normal Fall Risk - NFR) were determined by ABC scores; discriminant function analysis (DFA) was employed.

Main Results:

  • The IFR group exhibited significantly poorer mobility (MSWS-12, 6MW, steps/day) compared to the NFR group, even after controlling for disability.
  • DFA identified MSWS-12 and 6MW scores as significant predictors of fall risk group membership.
  • These two mobility measures explained 55% of the variance in fall risk classification.

Conclusions:

  • Mobility deficits are strongly associated with increased fall risk in persons with MS.
  • Rehabilitation programs for individuals with MS, particularly those at increased fall risk, should prioritize mobility interventions.