Related Experiment Video
Updated: Mar 10, 2026
10:28
Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
6.1K
The coronary sinus reducer: clinical evidence and technical aspects
Francesco Giannini1,2, Andrea Aurelio1,3, Richard J Jabbour1,2
1a Interventional Cardiology Unit , San Raffaele Hospital , Milan , Italy.
Expert Review of Cardiovascular Therapy
|December 10, 2016
Summary
The Coronary Sinus Reducer offers a new treatment for chronic refractory angina in patients ineligible for surgery. This device improved symptoms in a recent clinical trial, addressing an unmet need for effective therapies.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Chronic refractory angina significantly impacts quality of life and exercise capacity.
- Patients often remain symptomatic despite optimal medical therapy and are not candidates for revascularization.
- There is a critical unmet need for novel therapies to manage refractory angina and reduce healthcare costs.
Purpose of the Study:
- To review the clinical evidence and technical aspects of the Coronary Sinus Reducer.
- To evaluate the efficacy of the Coronary Sinus Reducer in patients with refractory angina unsuitable for revascularization.
Main Methods:
- Review of clinical evidence and technical aspects of the Coronary Sinus Reducer.
- Analysis of a randomized, double-blind, multi-center clinical trial involving 104 refractory angina patients.
- Comparison of the Coronary Sinus Reducer against a placebo.
Main Results:
- The Coronary Sinus Reducer is a percutaneous device designed to narrow the coronary sinus.
- Potential mechanisms include improved blood redistribution and promotion of neoangiogenesis.
- A clinical trial demonstrated a statistically significant benefit in symptom improvement compared to placebo.
Conclusions:
- The Coronary Sinus Reducer represents a promising new therapeutic option for refractory angina.
- This device may alleviate myocardial ischemia by altering coronary sinus hemodynamics.
- Further evaluation is warranted to establish its role in managing this challenging patient population.
Related Concept Videos
01:27Coronary Artery Disease V: Interprofessional Care
357
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
357
01:30Acute Coronary Syndrome III: Diagnostic Studies
357
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
357
01:28Acute Coronary Syndrome IV: Interprofessional Care
374
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
374
01:30Coronary Artery Disease III: Clinical Manifestations
504
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
504
01:26Coronary Artery Disease IV: Preventive Measures
790
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
790
01:26Acute Coronary Syndrome V: Nursing Management
435
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
435