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Ketoconazole therapy in a dog with systemic cryptococcosis
G D Mason1, M A Labato, A Bachrach
1Department of Small Animal Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
Journal of the American Veterinary Medical Association
|October 1, 1989
Summary
A dog with systemic cryptococcosis, presenting with eye and lung issues, was successfully treated with ketoconazole. This antifungal medication led to clinical remission and was well-tolerated over a 12-month treatment period.
Area of Science:
- Veterinary Medicine
- Mycology
- Infectious Diseases
Background:
- Systemic fungal infections can pose significant health risks in domestic animals.
- Cryptococcosis, caused by *Cryptococcus* species, is a notable systemic mycosis affecting dogs.
Observation:
- A 2-year-old dog presented with bilateral chorioretinitis and a cough, indicative of systemic illness.
- Diagnostic evaluation included trans-tracheal aspirate and cryptococcal latex-particle agglutination antigen testing.
Findings:
- Systemic cryptococcosis was confirmed as the diagnosis.
- Treatment with ketoconazole, an imidazole antifungal, resulted in clinical remission.
- Serial antigen titers effectively monitored treatment efficacy.
- The 12-month ketoconazole therapy was well-tolerated by the canine patient.
Implications:
- Ketoconazole is an effective treatment option for canine systemic cryptococcosis.
- Monitoring antigen titers is a valuable tool for assessing treatment response in fungal infections.
- Early diagnosis and treatment are crucial for favorable outcomes in systemic mycoses in dogs.