Novel antitumor antibiotic phospholine. 2. Structure determination
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T Ozasa1, K Tanaka, M Sasamata
1Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|September 1, 1989
Abstract:
Phospholine, an antitumor antibiotic, has the molecular formula of C25H40NO8P and possesses a delta-lactone and a phosphoric acid ester as functional groups. Its structure was determined based on interpretation of fast atom bombardment MS, 1H NMR, 13C NMR, 1H-1H correlation spectroscopy (COSY), 13C-1H COSY, heteronuclear multiple bond correlation spectroscopy, elemental analysis and chemical modifications.