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A new immunomodulator, FR-901235.
T Shibata1, M Nishikawa, Y Tsurumi
1Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
The Journal of Antibiotics
|September 1, 1989
Summary
FR-901235, a novel immunoactive substance from Paecilomyces carneus, restores suppressed lymphocyte proliferation. It also partially reverses impaired delayed-type hypersensitivity in tumor-bearing mice.
Area of Science:
- Immunology
- Mycology
- Pharmacology
Background:
- The immune system's ability to respond to stimuli can be compromised.
- Tumor-bearing states often lead to immune suppression.
- Identifying novel immunomodulatory agents is crucial for therapeutic development.
Purpose of the Study:
- To investigate the immunomodulatory effects of FR-901235.
- To determine if FR-901235 can restore immune responses suppressed by an immunosuppressive factor.
- To evaluate the efficacy of FR-901235 in a tumor-bearing mouse model.
Main Methods:
- FR-901235 was isolated from the fungus Paecilomyces carneus F-4882.
- Mitogen-induced lymphocyte proliferation assays were performed in the presence of an immunosuppressive factor and FR-901235.
- Delayed-type hypersensitivity responses to sheep red blood cells were assessed in tumor-bearing mice treated with FR-901235.
Main Results:
- FR-901235, an immunoactive substance, was produced by Paecilomyces carneus.
- FR-901235 restored mitogen-induced lymphocyte proliferation suppressed by an immunosuppressive factor.
- FR-901235 partially restored impaired delayed-type hypersensitivity in tumor-bearing mice.
Conclusions:
- FR-901235 exhibits significant immunomodulatory properties.
- This novel substance demonstrates potential in counteracting immune suppression.
- FR-901235 warrants further investigation as a therapeutic agent for immune dysfunction.