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Synthesis and biological activity of the two isomeric 2'-C-methyl daunomycins
V Rocherolle1, A Olesker, G Lukacs
1Institut de Chimie des Substances Naturelles du C.N.R.S., Gif-sur-Yvette, France.
The Journal of Antibiotics
|September 1, 1989
Abstract:
The title new daunorubicin analogues have been prepared from methyl 4,6-O-benzylidene-2-C-methyl-alpha-D-ribo-hexopyranosid-3-ulose and daunomycinone. The antitumor activity of these compounds was very similar to that of daunorubicin.