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Updated: Mar 10, 2026

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

Published on: November 17, 2021

Provenance information as a tool for addressing engineered nanoparticle reproducibility challenges.

Donald R Baer¹, Prabhakaran Munusamy¹, Brian D Thrall¹

¹Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352.

|December 13, 2016

Summary

Tracking nanoparticle provenance is crucial for consistent research. Documenting synthesis, storage, and handling minimizes variability and improves reproducibility in nanoparticle applications.

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Area of Science:

Materials Science
Nanotechnology
Biotechnology

Background:

Nanoparticles are vital in biological and technological fields.
Inconsistent nanoparticle properties hinder research and application.
Lack of detailed sample history (synthesis, storage, processing) is a key issue.

Purpose of the Study:

To highlight the importance of nanoparticle provenance.
To address challenges in producing and delivering consistent nanoparticles.
To propose provenance tracking as a solution for reproducibility.

Main Methods:

Defining nanoparticle provenance as origin and handling history.
Emphasizing the need for comprehensive records of synthesis and post-synthesis events.
Discussing the impact of time and environmental conditions on particle properties.

Main Results:

Incomplete particle history contributes to variability.
Changes in particles over time necessitate tracking.
Provenance information can identify sources of inconsistency.

Conclusions:

Establishing a clear record of nanoparticle provenance is essential.
Tracking provenance helps reduce particle variability.
Improved provenance management enhances research reproducibility.