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Prevalent peripheral arterial disease and inflammatory burden

Jane A Cauley1, Ahmed M Kassem2, Nancy E Lane3

  • 1Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, A510 Crabtree Hall, Pittsburgh, PA, 15261, USA. jcauley@edc.pitt.edu.

BMC Geriatrics
|December 13, 2016
PubMed
Abstract

Insights

Increased inflammatory burden is linked to peripheral arterial disease (PAD), similar to the impact of aging. Smoking further contributes to this inflammation-PAD association, highlighting the importance of managing inflammatory markers.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Epidemiology

Background:

  • Inflammation is a known factor in atherosclerotic heart disease.
  • The role of inflammation in peripheral arterial disease (PAD) is less understood.
  • This study investigates the association between inflammatory burden and PAD.

Purpose of the Study:

  • To test the hypothesis that a composite index of inflammatory burden is associated with prevalent PAD.
  • To quantify the relationship between specific inflammatory markers and PAD.
  • To compare the impact of inflammatory burden on PAD to the effect of aging.

Main Methods:

  • Cross-sectional analysis of 903 community-dwelling men from the MrOS cohort.
  • Measurement of seven cytokines in blood samples.
  • Assessment of prevalent PAD using ankle-brachial index (ABI <0.9) and an inflammatory burden score.

Main Results:

  • 6.75% of men had prevalent PAD (ABI <0.9).
  • Higher levels of interleukin-6, tumor necrosis factor alpha, and C-reactive protein were associated with increased odds of PAD.
  • An inflammatory burden score (≥3 pro-inflammatory cytokines) was associated with 3.6 times increased odds of PAD.

Conclusions:

  • Inflammatory burden is significantly associated with prevalent PAD.
  • This association is comparable in magnitude to aging by 10 years.
  • Smoking's inflammatory effects contribute to the observed inflammation-PAD link.
Keywords:
Ankle-arm indexAnkle-brachial indexCytokineInflammationMenPeripheral arterial diseasePeripheral vascular diseaseSmoking

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