Related Experiment Video
Updated: Mar 10, 2026
07:12
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
4.3K
Cognition as a treatment target in depression
M Kaser1, R Zaman1, B J Sahakian1
1Department of Psychiatry, University of Cambridge, Cambridge,UK.
Psychological Medicine
|December 13, 2016
Summary
Cognitive dysfunction in depression persists even after mood recovery, impacting outcomes. New treatments must target these persistent neurocognitive deficits for better depression management.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Cognitive dysfunction is a significant issue in depression, linked to poor clinical outcomes and psychosocial impairment.
- Current depression treatments often fail to specifically address cognitive deficits, which can persist post-mood recovery.
Discussion:
- Persistent neurocognitive deficits, including memory and concentration problems, highlight a gap in current depression management strategies.
- Understanding the underlying brain systems implicated in depression-related cognitive dysfunction is crucial for developing targeted interventions.
Key Insights:
- Cognitive dysfunction in depression is a distinct and enduring problem requiring specific therapeutic attention.
- The persistence of memory and concentration issues underscores the need for treatments beyond mood symptom alleviation.
Outlook:
- Developing refined methods for assessing cognitive dysfunction in depression is essential.
- A comprehensive approach is needed to create novel treatments that specifically target and improve cognition in individuals with depression.
More Related Videos
Related Concept Videos
01:25Cognitive Therapy
1.4K
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
1.4K
01:18Depression: Overview
1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
01:25Beck's Cognitive Therapy
481
Cognitive therapy is a psychological approach designed to address distortions in thinking, which can lead to negative emotions and unrealistic beliefs. These cognitive distortions often influence how individuals interpret and respond to situations, exacerbating emotional distress. Below are some prevalent cognitive distortions, their characteristics, and examples of how they manifest in thought processes.
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
481
01:29The Influence of Cognition on Affect
265
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
265
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
776
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
776
01:23Antidepressant Drugs: MAOIs and Other Agents
1.1K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K