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Bicuspid aortic valve outcomes

Inês Rodrigues1, Ana F Agapito1, Lídia de Sousa1

  • 1Department of Cardiology,Centro Hospitalar de Lisboa Central,Hospital de Santa Marta,Lisbon,Portugal.

Cardiology in the Young
|December 13, 2016
PubMed

Insights

Adults with bicuspid aortic valve have excellent long-term survival but frequently experience cardiovascular events. Baseline aortic valve calcification and dysfunction predict these events.

Area of Science:

  • Cardiology
  • Congenital Heart Disease
  • Aortic Valve Disease

Background:

  • Bicuspid aortic valve is the most common congenital heart defect.
  • It is associated with valvular dysfunction, endocarditis, thoracic aorta dilatation, and dissection.

Purpose of the Study:

  • To assess the incidence of cardiac events in adults with bicuspid aortic valve.
  • To identify predictors of cardiac events in this population.

Main Methods:

  • Retrospective analysis of cardiac outcomes in ambulatory adults with bicuspid aortic valve.
  • Follow-up in a tertiary hospital center.
  • Kaplan-Meier curves and multivariate analysis were used.

Main Results:

  • 227 patients were followed for 13±9 years.
  • 38.8% experienced at least one cardiac outcome; 20-year incidence was 47±4%.
  • Baseline moderate-severe aortic valve dysfunction and calcification predicted composite endpoint.

Conclusions:

  • Long-term survival in bicuspid aortic valve patients is excellent.
  • Frequent cardiovascular events occur, with calcification and dysfunction as key predictors.
Abstract

Keywords:
bicuspidcongenitalAortaaortic valveheart defectssurvival

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