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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Mar 10, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

Embryos with morphokinetic abnormalities may develop into euploid blastocysts.

C Lagalla¹, N Tarozzi¹, R Sciajno¹

¹9.Baby Center for Reproductive Health, via Dante, 15-40125 Bologna, Italy.

Reproductive Biomedicine Online

|December 13, 2016

Summary

This summary is machine-generated.

Embryos with irregular cell division can self-correct chromosomal errors, forming euploid blastocysts. This

Keywords:

aneuploidy rescue arrayCGH irregular cell divisions morphokinetics morula compaction pre-implantation genetic screening time-lapse

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Area of Science:

Reproductive Biology
Human Embryology
Genetics

Background:

Irregular cleavage divisions in early human embryos are often associated with chromosomal abnormalities.
The developmental potential of embryos exhibiting irregular cleavage patterns remains a significant question in pre-implantation genetic screening (PGS).

Purpose of the Study:

To determine if embryos with irregular cleavage divisions can develop into euploid blastocysts.
To investigate potential self-correction mechanisms for chromosomal abnormalities during embryonic development.
To explore the role of morula compaction dynamics in aneuploidy management.

Main Methods:

Retrospective analysis of 791 embryos from 141 patients undergoing PGS using time-lapse imaging.
Evaluation of cell division patterns and morula compaction.
Chromosome screening of blastocyst trophectoderm biopsies and excluded cells using array-comparative genomic hybridization (aCGH).

Main Results:

276 embryos developed into blastocysts suitable for genetic analysis.
Analysis of excluded cells from partially compacted morulas suggested a potential 'aneuploidy rescue' mechanism.
This self-correction process appears less effective in older women and excluded cells are unreliable for determining embryo aneuploidy.

Conclusions:

Embryos with initial cleavage abnormalities may possess a mechanism to correct chromosomal errors, leading to euploid blastocysts.
Morula compaction dynamics, specifically the formation of partially compacted morulas, may facilitate the exclusion of aneuploid cells.
The findings challenge the use of excluded cells for cytogenetic assessment and highlight age-related differences in embryonic self-correction efficiency.