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Osteoclast Derivation from Mouse Bone Marrow
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Periostin: The bone and beyond.

L Idolazzi1, E Ridolo2, A Fassio1

  • 1Rheumatology Unit, Department of Medicine, University of Verona, Italy.

European Journal of Internal Medicine
|December 13, 2016
PubMed
Summary
This summary is machine-generated.

Periostin (PO), a protein involved in tissue repair, is increasingly linked to various diseases. Elevated PO levels may serve as a biomarker for specific asthma phenotypes and predict treatment response.

Keywords:
AsthmaBone metabolismFibrosisInflammationPeriostin

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Area of Science:

  • Biochemistry
  • Immunology
  • Pathophysiology

Background:

  • The interplay between bone metabolism, organ systems, and the immune system is increasingly recognized.
  • Periostin (PO) is a matricellular protein expressed in various tissues, crucial for injury repair.
  • Overexpression of PO is associated with inflammation, fibrosis, and tumorigenesis in several diseases.

Purpose of the Study:

  • To review the physiological and pathological roles of Periostin (PO).
  • To highlight the specific correlation between PO levels and lung diseases, particularly asthma.
  • To evaluate PO as a potential diagnostic and therapeutic target.

Main Methods:

  • Literature review of current knowledge on Periostin (PO).
  • Analysis of studies investigating PO in various pathophysiological conditions.
  • Focus on PO's role in asthma and its association with Th2-high phenotype.

Main Results:

  • PO plays a role in tissue repair but its overexpression is linked to disease.
  • PO is identified as a key inflammatory effector in asthma, associated with eosinophilia.
  • PO may differentiate between Th2-high and Th2-low asthma phenotypes and predict therapeutic response.

Conclusions:

  • Periostin (PO) is implicated in the pathophysiology of diverse diseases.
  • PO shows promise as a biomarker for asthma and a predictor of treatment efficacy.
  • Further research is needed to validate PO's clinical utility as a diagnostic marker or therapeutic target.