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Cardiac Magnetic Resonance Imaging at 7 Tesla
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"Molecular" MR imaging at high fields.

John C Gore1, Zhongliang Zu1, Ping Wang1

  • 1Vanderbilt University Institute of Imaging Science, 1161 21st Ave South, Nashville, TN 37212, USA.

Magnetic Resonance Imaging
|December 13, 2016
PubMed
Summary

High-field magnetic resonance imaging (MRI) offers enhanced sensitivity for molecular imaging. New intrinsic contrast mechanisms at 7T and above reveal tissue composition without contrast agents.

Keywords:
CESTChemical exchangeEndogenous contrastHigh fieldMagnetization transferMolecular imaging

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Area of Science:

  • Radiology
  • Molecular Imaging
  • Biophysics

Background:

  • Magnetic resonance imaging (MRI) and spectroscopy (MRS) are vital in radiology for evaluating biological processes.
  • Current MRI sensitivity for molecular changes is limited compared to nuclear imaging.
  • Advancements in very high-field (7T+) MRI systems present new avenues for molecular imaging.

Purpose of the Study:

  • To explore intrinsic contrast mechanisms in high-field MRI for molecular and cellular information.
  • To identify methods for deriving tissue composition without exogenous agents.
  • To leverage increased signal strength in 7T+ MRI for enhanced sensitivity and resolution.

Main Methods:

  • Utilizing intrinsic contrast mechanisms: imaging different nuclei (e.g., sodium), chemical shift differences (MRS), specific relaxation mechanisms, molecular exchange rates, and susceptibility differences.
  • Acquiring higher resolution images with increased sensitivity at higher magnetic fields.
  • Evaluating molecular and cellular-level tissue biology.

Main Results:

  • Identified 5 types of intrinsic contrast mechanisms for molecular imaging.
  • Demonstrated derivation of tissue composition information using intrinsic properties.
  • Higher field strengths (7T+) improve signal strength, enabling detection of subtle molecular changes.

Conclusions:

  • Very high-field MRI (7T+) significantly enhances molecular imaging capabilities.
  • Intrinsic contrast mechanisms provide valuable molecular and cellular insights without contrast agents.
  • Advanced MRI techniques are crucial for understanding tissue biology at the molecular level.