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Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Related Experiment Video

Updated: Mar 10, 2026

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

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Skin fibrosis: Models and mechanisms.

N N Do1, S A Eming1

  • 1Department of Dermatology, University of Cologne, 50937 Cologne, Germany.

Current Research in Translational Medicine
|December 13, 2016
PubMed
Summary

Understanding skin fibrosis is crucial for treating conditions like Scleroderma. This review explores mouse models for studying fibrosis mechanisms and testing new therapies.

Area of Science:

  • Cellular and Molecular Biology
  • Dermatology
  • Pathology

Background:

  • Matrix synthesis, deposition, and remodeling are vital for tissue homeostasis and repair.
  • Dysregulation of these processes leads to pathological conditions like skin fibrosis, seen in Scleroderma and excessive scarring.
  • The precise pathogenesis of tissue fibrosis remains incompletely understood, highlighting the need for further research.

Purpose of the Study:

  • To provide an overview of established and novel mouse models for investigating skin fibrosis.
  • To highlight the utility of these models in understanding fibrosis mechanisms.
  • To demonstrate their application in evaluating potential therapeutic strategies.

Main Methods:

  • Review and synthesis of existing literature on mouse models for skin fibrosis.
Keywords:
ModelsSkin fibrosis

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  • Categorization of models based on their relevance to fibrosis mechanisms.
  • Discussion of established and recently developed models.

    • Main Results:

    • Several mouse models exist that recapitulate aspects of human skin fibrosis.
    • These models allow for the study of cellular and molecular pathways involved in fibrosis development.
    • They serve as valuable platforms for preclinical testing of antifibrotic therapies.

    Conclusions:

    • Mouse models are essential tools for dissecting the complexities of skin fibrosis.
    • Continued development and application of these models are critical for advancing therapeutic interventions.
    • Further research using these models will improve our understanding and treatment of fibrotic diseases.