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Commentary on topic: Should all tests of cognitive function - Learning, memory, attention - Be eliminated from the
1Neurotoxicology Branch, Toxicity Assessment Division, MD B105-04, NHEERL, ORD, U.S. EPA, 109 T.W. Alexander Drive, Research Triangle Park, Durham, NC 27711, USA.
Neurotoxicology and Teratology
|December 13, 2016
Summary
Cognitive function tests assessing learning, memory, and attention are crucial for developmental neurotoxicity testing. Eliminating these essential assessments risks overlooking critical neurodevelopmental risks in children.
Area of Science:
- Neuroscience
- Toxicology
- Developmental Biology
Background:
- Developmental neurotoxicity testing evaluates adverse effects on the developing nervous system.
- Current protocols often include tests for cognitive functions like learning, memory, and attention.
Discussion:
- This commentary questions the proposal to remove cognitive function tests from required developmental neurotoxicity testing protocols.
- Such removal could hinder the accurate assessment of neurodevelopmental risks.
Key Insights:
- Cognitive function tests are vital for identifying subtle neurotoxic effects.
- Maintaining these tests ensures comprehensive safety evaluations for neurodevelopmental toxicants.
Outlook:
- Further discussion is needed on the necessity and scope of cognitive assessments in regulatory toxicology.
- Future research should focus on refining and validating sensitive cognitive endpoints for developmental neurotoxicity testing.
