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Updated: Mar 10, 2026

An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
Published on: December 31, 2017
Neuroprotection and secondary damage following spinal cord injury: concepts and methods
Brett J Hilton1, Aaron J Moulson1, Wolfram Tetzlaff2
1International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Abstract:
Neuroprotection refers to the attenuation of pathophysiological processes triggered by acute injury to minimize secondary damage. The development of neuroprotective treatments represents a major goal in the field of spinal cord injury (SCI) research. In this review, we discuss the strengths and limitations of the methodologies employed to assess secondary damage and neuroprotection in preclinical models of traumatic SCI. We also discuss modelling issues and how new tools might be exploited to study secondary damage and neuroprotection.

