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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

Updated: Mar 10, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Re-calculating! Navigating through the osteosarcoma treatment roadblock.

J McGuire1, T J Utset-Ward2, D R Reed3

  • 1Department of Tumor Biology, H. Lee Moffitt Cancer Research Center and Institute, 12902 Magnolia Dr. Tampa, FL, 33612, USA; Cancer Biology PhD Program, University of South Florida, Tampa, FL, 33612, USA.

Pharmacological Research
|December 13, 2016
PubMed
Summary
This summary is machine-generated.

Osteosarcoma survival rates have stagnated. Emerging targeted therapies, informed by genetic and microenvironmental research, offer new hope for improving patient outcomes beyond current chemotherapy and surgery.

Keywords:
BoneClinical trialsInhibitorsMetastasisMicroenvironmentOsteosarcoma

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Related Experiment Videos

Last Updated: Mar 10, 2026

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Area of Science:

  • Oncology
  • Cancer Research
  • Translational Medicine

Background:

  • Osteosarcoma survival rates have shown minimal improvement over the last 30 years.
  • Current treatments involve chemotherapy (doxorubicin, cisplatin, methotrexate) and surgical resection, with limited success in improving outcomes.
  • Advances in understanding osteosarcoma's genetics, signaling pathways, and microenvironment are crucial.

Purpose of the Study:

  • To review emerging targeted therapies for osteosarcoma.
  • To discuss the mechanisms of action of these novel agents.
  • To explore the potential of these therapies to improve patient survival rates.

Main Methods:

  • Literature review of current osteosarcoma research.
  • Analysis of emerging targeted therapies and their mechanisms.
  • Discussion of clinical translation pathways for novel treatments.

Main Results:

  • Identification of promising novel targeted agents based on disease understanding.
  • Review of mechanisms of action for these emerging therapies.
  • Exploration of potential clinical applications and translation strategies.

Conclusions:

  • Novel targeted therapies show promise for improving osteosarcoma patient survival.
  • Further research and clinical translation are essential to integrate these therapies into standard care.
  • A deeper understanding of disease biology fuels the development of more effective treatments.