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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Related Experiment Video

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Improving Reproducibility to Meet Minimal Information for Studies of Extracellular Vesicles 2018 Guidelines in Nanoparticle Tracking Analysis

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Enhancing reproducibility for computational methods

Victoria Stodden¹, Marcia McNutt², David H Bailey³

¹University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. vcs@stodden.net.

Science (New York, N.Y.)

|December 13, 2016

Summary

No abstract available in PubMed .

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