Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

8.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Human Genetics01:28

Human Genetics

1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.3K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.3K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.7K
The Ras Gene02:38

The Ras Gene

7.4K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
7.4K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

15.2K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SIGNIFIED: whole-body MRI screening in Li-Fraumeni syndrome in the UK.

ESMO open·2026
Same author

Li Fraumeni syndrome in the UK: clinical characteristics and outcomes of TP53 carriers.

ESMO open·2025
Same author

Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.

British journal of cancer·2025
Same author

Genetics of prostate cancer and its utility in treatment and screening.

Advances in genetics·2021
Same author

Runs of homozygosity and testicular cancer risk.

Andrology·2019
Same author

Cervical Spine Fractures in Patients Undergoing Palliative Radiotherapy to the Cervical Spine: Implications for Practice.

Clinical oncology (Royal College of Radiologists (Great Britain))·2018

Related Experiment Video

Updated: Mar 10, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.9K

Genetic predisposition to prostate cancer.

S Benafif1,2, R Eeles3,2

  • 1Institute of Cancer Research, Oncogenetics, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

British Medical Bulletin
|December 13, 2016
PubMed
Summary

Genetic factors significantly influence prostate cancer (PrCa) risk. Identifying genetic variants can improve screening and personalize treatment for this common male cancer.

Keywords:
GWASSNPgeneticsgenome-wide association studypersonalised medicineprostate cancerscreening

More Related Videos

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

9.2K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.9K

Related Experiment Videos

Last Updated: Mar 10, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

2.9K
Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

9.2K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

47.9K

Area of Science:

  • Oncology
  • Genetics
  • Cancer Epidemiology

Background:

  • Prostate cancer (PrCa) is the most common non-cutaneous cancer in UK men.
  • Epidemiological and twin studies indicate a genetic contribution to PrCa aetiology.
  • Family history of PrCa doubles the risk for first-degree relatives.

Purpose of the Study:

  • To review the genetic factors contributing to prostate cancer risk.
  • To explore the potential of genetic profiling for targeted screening and personalized treatment.
  • To highlight areas for future research in PrCa genetics.

Main Methods:

  • Review of key published literature on PrCa genetics.
  • Analysis of findings from linkage, genetic sequencing, and genome-wide association studies (GWAS).
  • Examination of emerging data on genetic mutations in castrate-resistant PrCa.

Main Results:

  • Rare, moderate-to-high-risk gene loci and common single-nucleotide polymorphisms (SNPs) associated with PrCa risk have been identified.
  • Some identified loci and SNPs require further replication and validation.
  • Mutations in DNA repair genes are emerging as relevant in castrate-resistant disease.

Conclusions:

  • Germline SNP profiles and high-risk genetic variants offer potential for targeted PrCa screening, improving upon PSA screening limitations.
  • Incorporating genetic information into PrCa management is under investigation.
  • Understanding germline genetic defects is crucial for developing targeted screening, prevention, and personalized treatment strategies for PrCa.