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Updated: Mar 10, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

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The interferon paradox: can inhibiting an antiviral mechanism advance an HIV cure?

Steven G Deeks, Pamela M Odorizzi, Rafick-Pierre Sekaly

    The Journal of Clinical Investigation
    |December 13, 2016
    PubMed

    While antiretroviral therapy (ART) has improved the quality of life and increased the life span of many HIV-infected individuals, this therapeutic strategy has several limitations, including a lack of efficacy in fully restoring immune function and a requirement for life-long treatment. Two studies in this issue of the JCI use a humanized mouse model and demonstrate that type I interferon (IFN) is induced early during HIV infection and that type I IFN-associated gene signatures persist, even during ART. Importantly, blockade of type I IFN improved immune function, reduced the HIV reservoir, and caused a delay in viral rebound after ART interruption. Together, these two studies support further evaluation of IFN blockade as a supplement to ART.

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