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Related Experiment Videos

Tonsillar granular cell tumour in a cat.

R B Wilson1, M A Holscher, T T Casey

  • 1Department of Pathology, Vanderbilt Medical Center, Nashville, TN 37232.

Journal of Comparative Pathology
|July 1, 1989
PubMed
Summary

A granular cell tumour was diagnosed in a cat using microscopic analysis. Immunohistochemistry for S-100 protein and neuron-specific enolase was negative, differing from human cases.

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Area of Science:

  • Veterinary Pathology
  • Comparative Oncology

Background:

  • Granular cell tumours (GCTs) are rare neoplasms.
  • While common in humans, GCTs in felines are infrequently reported.
  • Understanding feline GCTs aids comparative pathology.

Purpose of the Study:

  • To diagnose and characterize a granular cell tumour in a feline patient.
  • To compare the immunohistochemical profile of feline GCT with human GCT.

Main Methods:

  • Diagnosis was confirmed through light and electron microscopy.
  • Immunohistochemistry was performed for S-100 protein and neuron-specific enolase.

Main Results:

  • Microscopic examination confirmed the diagnosis of granular cell tumour.
  • Immunohistochemical staining for S-100 protein was negative.
  • Immunohistochemical staining for neuron-specific enolase was negative.

Conclusions:

  • This study reports a case of feline granular cell tumour.
  • The immunohistochemical profile (negative S-100 and NSE) differs from typical human GCTs.
  • Further research is needed to elucidate the specific markers for feline GCTs.

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