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Published on: March 24, 2017
Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases
Youn Kyung Houh1, Kyung Eun Kim2, Hyun Jeong Park3
1Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, Korea. bobada6025@gmail.com.
Abstract:
Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.
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