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A cortical-hippocampal-cortical loop of information processing during memory consolidation
Gideon Rothschild1, Elad Eban2, Loren M Frank1,3
1Department of Physiology and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, USA.
Nature Neuroscience
|December 13, 2016
Summary
During sleep, specific auditory cortex activity patterns predict and influence hippocampal replay content during sharp-wave ripples (SWRs), suggesting cortical input shapes memory consolidation.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Memory Consolidation
Background:
- Hippocampal replay during sharp-wave ripples (SWRs) is crucial for memory consolidation.
- The influence of neocortical activity changes on SWR replay content is not well understood.
Purpose of the Study:
- To investigate the role of auditory cortex (AC) activity in shaping hippocampal replay content during SWRs.
- To explore the rapid cortical-hippocampal-cortical loop during sleep.
Main Methods:
- Recorded neural activity in rat auditory cortex and hippocampus during a sound-guided task and subsequent sleep.
- Analyzed patterns of neural activity preceding and during SWRs.
- Manipulated AC activity using auditory stimulation during sleep.
Main Results:
- Auditory cortex activation patterns preceded and predicted hippocampal replay content during SWRs.
- Hippocampal activity patterns during SWRs predicted subsequent auditory cortex activity.
- Auditory stimulation during sleep biased AC activity, which in turn predicted hippocampal activity.
Conclusions:
- A rapid, bidirectional cortical-hippocampal-cortical loop operates around SWRs.
- Specific cortical representations activated during sleep can influence the content of memory consolidation.
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