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End-stage renal disease in Tunisian infants: Etiology and outcome

M Jellouli1, A Boussetta1, K Abidi1

  • 1Department of Pediatric Nephrology, Charles Nicolle Hospital, Tunis, Tunisia.

Indian Journal of Nephrology
|December 13, 2016
PubMed

Insights

End-stage renal disease (ESRD) in infants is often caused by congenital anomalies or hereditary conditions. Peritoneal dialysis was the primary treatment, but infections and cardiovascular issues led to a significant mortality rate in Tunisian infants.

Area of Science:

  • Pediatric Nephrology
  • Infant Health
  • Renal Disease Research

Background:

  • End-stage renal disease (ESRD) in infants presents unique etiological and therapeutic challenges.
  • Understanding infant ESRD is crucial for developing effective pediatric kidney care strategies.

Purpose of the Study:

  • To investigate the primary causes of ESRD in infants.
  • To describe the outcomes and mortality rates associated with infant ESRD in Tunisia.

Main Methods:

  • Retrospective study conducted over 15 years (1998-2013) at Charles Nicolle Hospital.
  • Analysis of data from 24 infants diagnosed with ESRD.
  • Review of etiologies, treatments (peritoneal dialysis), complications (peritonitis), and mortality causes.

Main Results:

  • Congenital Anomalies of the Kidneys and Urinary Tract (CAKUT) and hereditary renal diseases were the leading causes (9 infants each).
  • Peritoneal dialysis was used for all patients, with 16 experiencing peritonitis.
  • The mortality rate was 28%, primarily due to cardiovascular diseases and infections.

Conclusions:

  • Infant ESRD in Tunisia is predominantly caused by CAKUT and hereditary conditions.
  • Peritoneal dialysis is a common treatment, but complications like peritonitis are frequent.
  • High mortality rates underscore the need for improved management strategies for pediatric renal disease.

Keywords:
Dialysisend-stage renal diseaseinfantmortality

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