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Correlations Between Changes in Undercarboxylated Osteocalcin and Muscle Function in Hypoparathyroidism.

Torben Harslof1, Tanja Sikjaer1, Leif Mosekilde1

  • 1Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Tage-Hansensgade 2, Aarhus C, Denmark.

International Journal of Endocrinology and Metabolism
|December 13, 2016
PubMed
Summary

Undercarboxylated osteocalcin (ucOC) did not significantly impact muscle function in hypoparathyroid patients. Further research in larger trials is needed to confirm these findings and explore the bone-muscle relationship.

Keywords:
Clinical TrialHypoparathyroidismMuscle FunctionUndercarboxylated Osteocalcin

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Muscle Physiology

Background:

  • The interplay between bone and muscle is increasingly recognized.
  • Undercarboxylated osteocalcin (ucOC), a bone-derived protein, is hypothesized to influence muscle mass and strength.
  • Prospective human data on this relationship are lacking.

Purpose of the Study:

  • To investigate the prospective relationship between changes in undercarboxylated osteocalcin (ucOC) and muscle function in patients with hypoparathyroidism.
  • To determine if parathyroid hormone (PTH) treatment, which increases ucOC, affects muscle mass, strength, or function.

Main Methods:

  • A secondary analysis of a randomized, placebo-controlled trial involving hypoparathyroid patients treated with PTH or placebo.
  • Muscle mass assessed by Dual-energy X-ray Absorptiometry (DXA).
  • Muscle strength measured by maximal voluntary isometric strength testing and functional tests including repeated chair stands and Timed Up and Go, with postural stability assessed.

Main Results:

  • A positive and significant association was found between the ratio of ucOC to total osteocalcin (ucOC%/OC%) and the percentage change in maximal elbow extension force (β = 0.28, P = 0.034).
  • No other significant associations were observed between ucOC changes and various measures of muscle mass, strength, or function.
  • The single significant finding may be a false positive due to multiple statistical tests.

Conclusions:

  • The study's results do not support a role for ucOC in modulating muscle function in humans with hypoparathyroidism.
  • Findings contradict previous cross-sectional human studies, highlighting the limitations of inferring causality from such designs.
  • Larger, prospective randomized trials, including healthy individuals, are recommended to validate these findings and elucidate the ucOC-muscle relationship.