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Hepatic Epithelioid Angiomyolipoma: Case Series.
Hetal Talati1, Jasim Radhi1, Snezana Popovich1
1Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3V7, Canada.
Gastroenterology Research
|December 13, 2016
Summary
Hepatic epithelioid angiomyolipoma (AML) is a rare liver tumor. Accurate diagnosis relies on immunohistochemistry markers like HMB-45, especially when imaging is inconclusive.
Area of Science:
- Pathology
- Oncology
- Radiology
Background:
- Hepatic epithelioid angiomyolipoma (AML) is a rare mesenchymal neoplasm.
- It occurs in both sexes but is most common in adult females.
- Diagnosis can be challenging due to imaging limitations, particularly with minimal fat.
Observation:
- Epithelioid AML can mimic hepatocellular carcinoma histomorphologically.
- Key diagnostic markers include strong positivity for homatropine methylbromide-45 (HMB-45) and smooth muscle actin.
- These immunohistochemical findings are crucial for pathological confirmation.
Findings:
- Hepatic epithelioid AML presents as a well-circumscribed hepatic mass.
- Fatty components may be scant or absent, complicating imaging-based diagnosis.
- Immunohistochemistry confirms the diagnosis by identifying specific tumor markers.
Implications:
- Consider hepatic epithelioid AML in the differential diagnosis of liver masses.
- Awareness of its presentation is vital for clinicians and radiologists.
- Accurate pathological diagnosis ensures appropriate patient management.
