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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Prosthetic vascular graft infection and prosthetic joint infection caused by Pseudomonas stutzeri
Michael J Bonares1, Alon Vaisman2, Abdu Sharkawy3
1Division of General Internal Medicine, Department of Medicine, University of Toronto, 190 Elizabeth Street, Toronto, ON M5G 2C4, Canada.
Abstract:
Pseudomonas stutzeri is infrequently isolated from clinical specimens, and if isolated, more likely represents colonization or contamination rather than infection. Despite this, there are dozens of case reports which describe clinically significant P. stutzeri infections at variable sites. A 69-year-old man had a P. stutzeri infection of a prosthetic vascular graft infection, which he received in Panama City. He was successfully treated with a single antipseudomonal agent for 6 weeks and the removal of the infected vascular graft. A 70-year-old man had a P. stutzeri infection of a prosthetic joint, which was successfully treated with a single anti-pseudomonal agent for 6 weeks. There is only one other documented case of a prosthetic vascular graft infection secondary to P. stutzeri. There are 5 documented cases of P. stutzeri prosthetic joint infections. The previous cases were treated with antibiotics and variably, source control with the removal of prosthetic material. Most cases of P. stutzeri infection are due to exposure in health care settings. Immunocompromised states such as HIV or hematological and solid tumor malignancies are risk factors for P. stutzeri infection. Infections caused by P. stutzeri are far less frequent and less fatal than those caused by P. aeruginosa. The etiology of a P. stutzeri infection could be exposure to soil and water, but also contaminated material in the health care setting or an immunocompromised state. Iatrogenic infections that are secondary to health care tourism are a potential cause of fever in the returned traveler.
Insights
Pseudomonas stutzeri infections, though rare, can cause significant issues with prosthetic devices. Successful treatment often involves antibiotics and removal of the infected material.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Case Reports
Background:
- Pseudomonas stutzeri is rarely isolated from clinical samples, often indicating colonization rather than infection.
- Despite its rarity, P. stutzeri has been documented in clinically significant infections at various sites.
- Risk factors include immunocompromised states and exposure to healthcare settings.
Purpose of the Study:
- To highlight documented cases of Pseudomonas stutzeri prosthetic device infections.
- To discuss treatment strategies for P. stutzeri infections involving prosthetic materials.
- To underscore the potential for P. stutzeri as a cause of infection in returned travelers.
Main Methods:
- Review of case reports detailing P. stutzeri infections.
- Analysis of treatment outcomes for prosthetic device infections.
- Comparison of P. stutzeri infections with those caused by P. aeruginosa.
Main Results:
- Two cases presented: prosthetic vascular graft infection and prosthetic joint infection.
- Both patients were successfully treated with a 6-week course of a single antipseudomonal agent and source control.
- P. stutzeri prosthetic infections are rare, with limited documented cases.
Conclusions:
- Pseudomonas stutzeri can cause serious prosthetic device infections.
- Treatment requires a combination of antibiotics and surgical intervention (source control).
- Healthcare-associated infections and travel-related exposures are potential etiologies.
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