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Hepatitis B virus infection and risk of coronary artery disease: a meta-analysis

Karn Wijarnpreecha1, Charat Thongprayoon1, Panadeekarn Panjawatanan2

  • 1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.

Annals of Translational Medicine
|December 13, 2016
PubMed

Insights

This meta-analysis found no significant link between Hepatitis B virus (HBV) infection and coronary artery disease (CAD). The study suggests HBV-infected individuals do not face a higher risk of developing CAD.

Area of Science:

  • Cardiology
  • Hepatology
  • Epidemiology

Background:

  • Chronic inflammation in Hepatitis B virus (HBV) infection may link to coronary artery disease (CAD).
  • Existing research on the association between HBV and CAD presents conflicting findings.
  • This meta-analysis aimed to clarify the risk of CAD in HBV-infected patients.

Approach:

  • A systematic literature search was conducted on MEDLINE and EMBASE up to June 2016.
  • Five studies (3 cross-sectional, 1 case-control, 1 cohort) comparing CAD risk in HBV-infected vs. non-infected individuals were included.
  • A random-effect model and generic inverse variance method were used to pool data.

Key Points:

  • The analysis included a total of five studies with varying designs.
  • The pooled results indicated no statistically significant increase in the risk of CAD among patients with chronic HBV infection.
  • The odds ratio for CAD in HBV-infected patients was 0.68 (95% CI, 0.40-1.13).

Conclusions:

  • This meta-analysis concludes that there is no significantly increased risk of coronary artery disease (CAD) in patients infected with the Hepatitis B virus (HBV).
  • The findings do not support a causal relationship between HBV infection and the development of CAD based on current evidence.
Abstract

Keywords:
Hepatitis B virus (HBV)coronary artery disease (CAD)heart attackmeta-analysismyocardial infarction

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