Related Experiment Video
Updated: Mar 10, 2026
Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
Hepatitis B virus infection and risk of coronary artery disease: a meta-analysis
Karn Wijarnpreecha1, Charat Thongprayoon1, Panadeekarn Panjawatanan2
1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA.
Insights
This meta-analysis found no significant link between Hepatitis B virus (HBV) infection and coronary artery disease (CAD). The study suggests HBV-infected individuals do not face a higher risk of developing CAD.
Area of Science:
- Cardiology
- Hepatology
- Epidemiology
Background:
- Chronic inflammation in Hepatitis B virus (HBV) infection may link to coronary artery disease (CAD).
- Existing research on the association between HBV and CAD presents conflicting findings.
- This meta-analysis aimed to clarify the risk of CAD in HBV-infected patients.
Approach:
- A systematic literature search was conducted on MEDLINE and EMBASE up to June 2016.
- Five studies (3 cross-sectional, 1 case-control, 1 cohort) comparing CAD risk in HBV-infected vs. non-infected individuals were included.
- A random-effect model and generic inverse variance method were used to pool data.
Key Points:
- The analysis included a total of five studies with varying designs.
- The pooled results indicated no statistically significant increase in the risk of CAD among patients with chronic HBV infection.
- The odds ratio for CAD in HBV-infected patients was 0.68 (95% CI, 0.40-1.13).
Conclusions:
- This meta-analysis concludes that there is no significantly increased risk of coronary artery disease (CAD) in patients infected with the Hepatitis B virus (HBV).
- The findings do not support a causal relationship between HBV infection and the development of CAD based on current evidence.
Background:
Hepatitis B virus (HBV)-infected patients might be associated with coronary artery disease (CAD) from process of chronic inflammation. However, available studies yield conflicting results. This meta-analysis was performed to assess risk of CAD in HBV-infected patients.
Methods:
We searched MEDLINE and EMBASE for relevant literatures from database inception to June 2016. Studies comparing the risk of CAD among HBV-infected patients versus subjects without HBV infection using hazard ratio (HR), odd ratios, or relative risk (RR) were included. Random-effect model and generic inverse variance method were used to combine odds ratio (OR) and 95% confidence interval (CI).
Results:
A total of five studies, including three cross-sectional studies, one case-control study, and one cohort study, were subjected to analysis. The result demonstrates no significant risk of CAD among chronic HBV-infected patients and subjects without HBV infection (OR, 0.68; 95% CI, 0.40-1.13).
Conclusions:
This meta-analysis did not demonstrate a significantly increased risk of CAD among HBV-infected patients.
