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Updated: Mar 10, 2026
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Transition-metal-free B-B and B-interelement reactions with organic molecules
Ana B Cuenca1, Ryosuke Shishido2, Hajime Ito2
1Dept Física Química e Inorgánica, University Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain. mariaelena.fernandez@urv.cat and Dept. Química Orgánica, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta, 390, Barcelona 08017, Spain.
Abstract:
This review is a guided tour along the activation modes and reactivity of B-B, B-Si, B-N, B-S, B-Se and B-P reagents, in the absence of any transition metal complex. Here are disclosed the general concepts related to the homolytic and heterolytic cleavage of B-B and B-interelement bonds, as well as the generation of new C-B and C-interelement bonds, in a selective way. The greener consequences of these novel routes facilitate the gram scale preparations of target functionalised organic compounds. Intrinsic data about the suggested mechanisms and spectroscopic evidence that supports the innovative theories are provided along the review. Since this is a stimulating area of work that has emerged within the last decade, this overview serves as the basis to understand the new trends and hopefully to generate inspiration for future discoveries in the field.
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