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Updated: Mar 10, 2026
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Flow cytometry minimal residual disease after allogeneic transplant for chronic lymphocytic leukemia
Caroline Algrin1,2, Jean-Louis Golmard3, Mauricette Michallet4
1Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Objectives:
This study investigates whether achieving complete remission (CR) with undetectable minimal residual disease (MRD) after allogeneic stem cell transplantation (allo-SCT) for chronic lymphocytic leukemia (CLL) affects outcome.
Methods:
We retrospectively studied 46 patients transplanted for CLL and evaluated for post-transplant MRD by flow cytometry.
Results:
At transplant time, 43% of the patients were in CR, including one with undetectable MRD, 46% were in partial response, and 11% had refractory disease. After transplant, 61% of the patients achieved CR with undetectable MRD status. By multivariate analysis, reaching CR with undetectable MRD 12 months after transplant was the only factor associated with better progression-free survival (P = 0.02) and attaining undetectable MRD, independently of the time of negativity, was the only factor that correlated with better overall survival (P = 0.04).
Conclusion:
Thus, achieving undetectable MRD status after allo-SCT for CLL is a major goal to improve post-transplant outcome.
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