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Hyaluronan in flexor tendon repair.

D Amiel¹, K Ishizue, E Billings

¹University of California, San Diego, La Jolla 92093.

The Journal of Hand Surgery

|September 1, 1989

Summary

Topical hyaluronic acid application during flexor tendon repair reduced adhesions and improved tendon gliding. This study in dogs suggests hyaluronan benefits tendon healing by decreasing inflammation and promoting cell involvement.

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Regenerative Medicine

Background:

Flexor tendon repair can lead to adhesions, restricting gliding function.
Hyaluronic acid (hyaluronan) is a key component of connective tissue with potential anti-inflammatory and lubricating properties.

Purpose of the Study:

To evaluate the efficacy of topical hyaluronan in reducing adhesions after flexor tendon repair.
To assess the impact of hyaluronan on the gliding function of repaired flexor tendons.

Main Methods:

A canine model was used, involving transection and repair of flexor tendons.
Hyaluronic acid (3.6 x 10^6 daltons) was applied topically to the repair site.
Immobilization for 5 weeks followed by gross and histologic evaluation.

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Main Results:

Topical hyaluronan application consistently affected the quality and quantity of adhesions.
Hyaluronan decreased peripheral inflammatory response around the repair site.
A beneficial effect on synovial sheath healing was observed, promoting contact healing.

Conclusions:

Topical hyaluronan demonstrates a beneficial effect in reducing adhesions post-flexor tendon repair.
Hyaluronan promotes a favorable healing environment, potentially improving functional outcomes.