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[The immune response following open-heart surgery]
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
|July 1, 1989
Summary
Open-heart surgery, particularly with cardiopulmonary bypass, causes significant immune suppression, including reduced lymphocytes and T cells. Simple deep hypothermia resulted in milder immune suppression, with a tendency for recovery post-surgery.
Area of Science:
- Immunology
- Cardiovascular Surgery
Context:
- Investigating immune responses after open-heart surgery.
- Comparing simple deep hypothermia with cardiopulmonary bypass and thoracic surgery.
Purpose:
- To assess changes in leukocyte and lymphocyte counts, lymphocyte subpopulations (T cells, B cells, Leu2a+, Leu3a+), and immunoglobulin levels (IgG, IgA, IgM) post-surgery.
- To evaluate the impact of simple deep hypothermia versus cardiopulmonary bypass on immune function.
Summary:
- Open-heart surgery with cardiopulmonary bypass led to prolonged leukocytosis and significant decreases in total lymphocytes and T cells (Leu2a+, Leu3a+).
- Simple deep hypothermia also caused leukocytosis and lymphopenia, but immune suppression was milder with a trend toward recovery by postoperative day three.
- Immunoglobulin levels remained within the normal range, with a notable increase in IgM after simple deep hypothermia.
Impact:
- Highlights the immunomodulatory effects of different surgical techniques and hypothermia levels.
- Suggests simple deep hypothermia may be associated with less severe immune suppression compared to cardiopulmonary bypass.
- Provides insights into postoperative immune recovery patterns relevant to surgical patient management.