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Opsoclonus in mumps and poliovirus type 3 encephalitides: a report of 2 cases
Abstract:
Two adult patients with opsoclonus and tremor of the whole body associated with viral infections are reported. The first man presented with mumps (parotitis, orchitis and encephalitis). Paired serum mumps titers were both 1:80. The second patient had conjunctivitis and dizziness. Acute and convalescent sera showed significant rise of poliovirus type 3 titer. Clonazepam attenuated the symptoms in both patients.
Insights
Viral infections can cause opsoclonus and whole-body tremor in adults. Clonazepam effectively reduced these symptoms in two patients with mumps and poliovirus infections, respectively.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Opsoclonus and tremor are rare neurological manifestations.
- Viral infections are potential triggers for these symptoms.
Observation:
- Two adult patients presented with opsoclonus and whole-body tremor.
- The first patient had mumps (parotitis, orchitis, encephalitis) with elevated mumps titers.
- The second patient experienced conjunctivitis and dizziness with a significant rise in poliovirus type 3 titer.
Findings:
- Both patients showed improvement in opsoclonus and tremor after administration of clonazepam.
- This suggests a potential therapeutic role for clonazepam in managing viral-induced opsoclonus-myoclonus syndrome.
Implications:
- Highlights the association between specific viral infections and opsoclonus-tremor syndrome.
- Suggests clonazepam as a viable treatment option for these neurological complications.
- Warrants further investigation into the pathophysiology and treatment of viral-induced neurological disorders.