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Erythrocyte deformability in diabetes mellitus
Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association
|March 1, 1989
Summary
Diabetic patients exhibit reduced red blood cell (RBC) filterability, indicating impaired blood flow. This defect is linked to metabolic derangements common in diabetes.
Area of Science:
- Hematology
- Diabetology
- Cardiovascular Research
Background:
- Erythrocyte filterability is a critical determinant of microvascular blood flow.
- Diabetes mellitus is associated with numerous complications, potentially linked to altered blood rheology.
Purpose of the Study:
- To investigate erythrocyte filterability in diabetic patients compared to healthy controls.
- To identify correlations between erythrocyte filterability and various metabolic and hematological parameters in diabetes.
Main Methods:
- Erythrocyte filterability was assessed using a filtration index (FI) in 34 diabetic patients and 43 normal subjects.
- Blood parameters including glucose, HbA1c, lipids, BUN, and complete blood count were measured.
- Multiple linear regression analysis was employed to determine predictors of FI.
Main Results:
- Diabetic patients showed significantly lower mean FI (3.47) than controls (4.03).
- Lower FI correlated inversely with fasting plasma glucose, triglycerides, blood urea nitrogen, HbA1c, MCHC, and WBC.
- Mean corpuscular volume (MCV) was lower in diabetics and positively correlated with FI.
Conclusions:
- Diabetic patients have impaired erythrocyte filterability, suggesting a rheological defect.
- Metabolic derangements in diabetes likely contribute to reduced RBC filterability, impacting microcirculation.