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Tumor Progression02:07

Tumor Progression

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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[Molecular Pathogenesis of Colorectal Cancer].

J Král, J Slyšková, P Vodička

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |December 14, 2016
    PubMed
    Summary

    Colorectal cancer (CRC) is a significant global health issue. Understanding the molecular basis of both hereditary and sporadic CRC is vital for effective treatment and prognosis.

    Keywords:
    colorectal cancer - pathogenesis - hereditary - sporadic - risk factorsThis work was supported by grant of Grant Agency of the Czech Republic No. 15-08239S.The authors declare they have no potential conflicts of interest concerning drugsproducts or services used in the study.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 3. 5. 2016Accepted: 2. 6. 2016.

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    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Colorectal cancer (CRC) is a leading cause of cancer incidence and mortality worldwide.
    • Over 50% of CRC patients in the Czech Republic are diagnosed with advanced disease.
    • CRC is genetically heterogeneous, with hereditary (5-10%) and sporadic (90-95%) forms.

    Purpose of the Study:

    • To summarize the molecular pathogenesis of sporadic and hereditary colorectal cancer.
    • To highlight the importance of understanding CRC molecular pathways for clinical applications.

    Main Methods:

    • Review of existing literature on colorectal cancer molecular pathogenesis.
    • Synthesis of information on genetic factors and mutations in CRC development.

    Main Results:

    • Identification of key genes and mutations involved in hereditary CRC (e.g., APC, MMR).
    • Overview of accumulated mutations in sporadic CRC (e.g., APC, KRAS, MMR, microRNA, CIMP).
    • Emphasis on the heterogeneity of CRC at the molecular level.

    Conclusions:

    • Knowledge of molecular pathogenesis is crucial for CRC treatment, risk assessment, prognosis, and follow-up.
    • This article provides a summary of the molecular basis for both sporadic and hereditary CRC.