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Delayed postoperative neurological deterioration from prolonged sodium nitroprusside administration. Case report
Z Ram1, R Spiegelman, G Findler
1Department of Neurosurgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Journal of Neurosurgery
|October 1, 1989
Summary
Sodium nitroprusside can cause cyanide poisoning, leading to coma in neurosurgical patients. Promptly stopping the drug and treating cyanide toxicity rapidly reversed the patient's critical condition.
Area of Science:
- Neurosurgery
- Toxicology
- Pharmacology
Background:
- Sodium nitroprusside is frequently utilized for inducing hypotension during neurosurgical operations.
- Its toxicity is attributed to hemodynamic effects and the generation of cyanide, a dangerous metabolite.