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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Parasite Infection, Carcinogenesis and Human Malignancy.
Hoang van Tong1, Paul J Brindley2, Christian G Meyer3
1Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Biomedical and Pharmaceutical Applied Research Center, Vietnam Military Medical University, Hanoi, Vietnam.
Parasitic infections, including helminths and protozoa, are linked to various cancers. Some parasites promote cancer, while others, like Trypanosoma cruzi, have dual roles, impacting carcinogenicity and anticancer properties.
Area of Science:
- Parasitology
- Oncology
- Infectious Diseases
Background:
- Environmental and physiological factors can induce cancer.
- Infections by viruses, bacteria, and parasites are recognized causes of human carcinogenicity.
Purpose of the Study:
- To review current concepts of carcinogenicity.
- To explore the associations between parasitic infections and cancer development.
Main Methods:
- Literature review of scientific studies on parasitic infections and cancer.
- Analysis of mechanisms underlying parasitic infection-induced carcinogenicity.
Main Results:
- Helminthic diseases like schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic.
- Trypanosoma cruzi (Chagas disease) exhibits dual roles in cancer development (carcinogenic and anticancer).
- Malaria is associated with endemic Burkitt lymphoma, requiring Epstein-Barr virus co-infection; Strongyloides stercoralis may co-factor T-cell lymphomas.
Conclusions:
- Parasitic infections play a significant role in human carcinogenicity through various mechanisms.
- Understanding these associations is crucial for cancer prevention and treatment strategies.
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