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Sex differences in cough reflex.

J Plevkova1, T Buday1, N Kavalcikova-Bogdanova1

  • 1Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Pathophysiology & Division of Neuroscience BioMed Martin, Slovakia.

Respiratory Physiology & Neurobiology
|December 14, 2016
PubMed
Summary
This summary is machine-generated.

Women experience persistent cough more often due to an exaggerated cough reflex. Research excluding females contributes to this knowledge gap, highlighting biological and behavioral sex differences in cough hypersensitivity.

Keywords:
CoughGender differencesHormonesHypersensitivity

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Area of Science:

  • Physiology
  • Sex Differences in Medicine
  • Cough Reflex

Background:

  • Postmenopausal women frequently present with intractable cough.
  • The underlying reasons for an exaggerated cough reflex in women remain unclear.
  • Exclusion of females in basic research creates a sex bias, hindering understanding of hypersensitive cough in women.

Purpose of the Study:

  • To explore the physiological basis of cough reflex differences between sexes.
  • To investigate biological, social, and behavioral factors contributing to sex-based variations in cough.
  • To understand the maturation differences in cough reflex development.

Main Methods:

  • Review of existing literature on cough physiology and sex differences.
  • Analysis of biological factors influencing cough reflex sensitivity.
  • Examination of social and behavioral influences on cough patterns and environmental exposures.

Main Results:

  • Biological and behavioral differences between men and women significantly impact cough physiology.
  • Gender influences behavioral patterns and environmental exposures, differing between sexes.
  • Maturation processes of the cough reflex may also exhibit sex-based variations.

Conclusions:

  • Sex differences in cough are influenced by a combination of biological, social, and behavioral factors.
  • Further research including females is crucial to understand and treat hypersensitive cough in women.
  • Addressing the sex bias in research is essential for advancing knowledge of cough reflex mechanisms.