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Heart failure - what's new and what's changed?
Paul D Callan1, Andrew L Clark2
1Advanced Heart Failure and Cardiac Transplantation, University Hospital of South Manchester, Manchester, UK paulcallan843@btinternet.com.
Clinical Medicine (London, England)
|December 14, 2016
Summary
Novel therapies are needed for heart failure with left ventricular systolic dysfunction, despite existing treatments. This review discusses recent trials like SERVE-HF, EMPA-REG, and PARADIGM-HF, highlighting care challenges.
Area of Science:
- Cardiology
- Clinical Trials
- Heart Failure Management
Background:
- Significant advancements in heart failure treatments over four decades exist.
- Persistent high morbidity and mortality necessitate novel therapeutic strategies.
- Growing heart failure population requires evolving specialist care models.
Purpose of the Study:
- To review recent evidence-based treatments for heart failure with left ventricular systolic dysfunction.
- To discuss findings from key clinical trials and their implications for heart failure specialists.
- To examine challenges in developing and delivering specialized heart failure care.
Main Methods:
- Review of randomized controlled trials including SERVE-HF (adaptive servo-ventilation) and EMPA-REG (diabetic agent).
- Analysis of further data from the PARADIGM-HF trial (sacubitril valsartan).
- Consideration of recent National Institute for Health and Care Excellence guidelines for acute heart failure.
Main Results:
- Adaptive servo-ventilation trial (SERVE-HF) findings are discussed.
- Potential benefits of a novel diabetic agent (EMPA-REG) for heart failure are explored.
- Further analyses of sacubitril valsartan (PARADIGM-HF) address unresolved questions.
Conclusions:
- Evidence-based treatments prolong life and reduce symptoms in heart failure.
- Novel therapies and optimized multidisciplinary care are crucial for managing heart failure.
- Developing and delivering specialized services face challenges but are essential for a growing patient population.
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