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Updated: Mar 10, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Breaking down the gut microbiome composition in multiple sclerosis.

Adrian Budhram¹, Seema Parvathy², Marcelo Kremenchutzky¹

¹Department of Clinical Neurological Sciences, Division of Neurology, University Hospital, London, ON, Canada.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|December 14, 2016

Summary

This summary is machine-generated.

The gut microbiome, a community of microorganisms, shows distinct differences in multiple sclerosis (MS) patients compared to healthy individuals. These gut microbiome alterations may play a role in MS immunopathogenesis and offer therapeutic targets.

Keywords:

Multiple sclerosis gut microbiome microbiota

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Area of Science:

Microbiology
Immunology
Neurology

Background:

The gut microbiome comprises a diverse community of microorganisms.
Its role in multiple sclerosis (MS) immunopathogenesis is an area of growing research interest.
This review critically examines existing literature on the gut microbiome in MS.

Purpose of the Study:

To review and synthesize current literature on the gut microbiome in MS.
To explore potential mechanistic links between gut microbiome alterations and MS.
To discuss therapeutic implications arising from these findings.

Main Methods:

A comprehensive literature search was conducted using PubMed and ECTRIMS meeting abstracts.
Included studies focused on the gut microbiome in MS patients.
Controlled studies comparing MS patients to healthy controls were prioritized.

Main Results:

Case-control studies consistently identified differences in the gut microbiome composition between MS patients and controls.
These findings suggest a potential link between gut microbial dysbiosis and MS.
Mechanistic pathways and therapeutic avenues are explored based on these differences.

Conclusions:

The gut microbiome is potentially linked to the immunopathogenesis of MS.
Emerging findings suggest avenues for therapeutic advancements in MS treatment.
Further systematic research is crucial in this developing field.