Related Experiment Video
Updated: Mar 10, 2026
Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Hindbrain Effects of L-Glutamate on Gastric Motility in Rats
Hong Zhao Sun1, Shu Zhen Zhao2, Xi Yun Cui2
1Key Laboratory of Animal Resistance, College of Life Science, Shandong Normal University, Jinan, Shandong, 250014, China; Department of Biological Science and Technology, Shandong Institute of Education, Jinan, Shandong, 250013, China.
Background:
There are no unanimous standpoints about the dorsal motor nucleus of the vagus (DMV) and nucleus of solitary tract (NTS) involving in the regulation of gastric motility up to now.
Methods:
In this study, we injected L-Glutamate (L-Glu), an incitant neurotransmitter in the central neural system, into DMV and NTS to further investigate the effects of the two nuclei on gastric motility. A latex balloon connected with a pressure transducer was inserted into the pylorus through the fundus for continuous recording of the change of gastric smooth muscle contractile curves.
Results:
L-Glu (10 nmol in 0.1 µl) microinjected into right DMV and NTS significantly inhibited gastric motility. We compared the effects of L-Glu (10 nmol) microinjected into the two nuclei, the L-Glu microinjected into right NTS had the greater inhibitory effect on gastric motility than microinjected into the right DMV. The physiological saline microinjection evoked no significant effect on gastric motility.
Conclusions:
L-Glu microinjected into right DMV and NTS evoked significant inhibition on gastric motility in rats. At equal dose of L-Glu, NTS had the greater inhibitory effect than DMV.
Related Concept Videos
01:28Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
01:20Gastrointestinal Motility Disorders