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Updated: Mar 10, 2026
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
Expression of C-Reactive Protein in Rectal Cancer
Paulo de Carvalho Contu1, Simone Santana Contu2, Mario Antonello Rosito3
1Post-Graduate Programme in Surgery, Hospital de Clínicas de Porto Alegre University Hospital, Federal University of Rio Grande do Sul, Brazil. Ramiro Barcelos, 2400 - 2° andar, Santa Cecília, Porto Alegre, RS, PO 90.035-930 Brazil; Division of Coloproctology, Department of Surgery, Hospital de Clínicas de Porto Alegre University Hospital, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Ramiro Barcelos, 2350 - sl 600, Santa Cecilia, Porto Alegre, RS, PO 90.035-930 Brazil.
Background:
The possible involvement of inflammation on colorectal carcinogenesis has potential prognostic, preventive and therapeutic implications. We investigated immunohistochemically whether C-reactive protein is expressed in human primary rectal adenocarcinoma and assessed its relationship with clinicopathological findings.
Methods:
Ninety-one rectal cancer samples and 22 normal control samples were immunohistochemically analysed.
Results:
Cell accumulation of C-reactive protein was observed in 65 (71%) out of 91 patients with rectal adenocarcinoma and in all 22 control cases (p < 0.01). No significant difference was observed regarding to clinicopathological features or survival rates, but a linear correlation between the positivity proportion of C-reactive protein and Dukes-Turnbull stage (p = 0.005) was observed.
Conclusions:
These data suggest that C-reactive protein might play a role in rectal carcinogenesis, but seems not to affect prognosis. Additional studies are warranted in larger population samples.
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